中药大生命科学与技术学院导师介绍：周长林

　　1、简历
　　周长林（博士/教授/博导），男，1964年1月生，1986、1989和1997年于华东理工大学生物工程专业分别获学士、硕士和博士学位，1999.4-2000.3年日本近畿大学药学部访问学者，2004.12-2005.11年美国Providence College生物系博士后。现任中国药科大学生命科学与技术学院副院长、微生物学教研室主任，担任中国微生物学会酶工程专业委员会委员、江苏省微生物学会理事,《药物生物技术》、《药学与临床研究》杂志编委。2008年被评为江苏省“青蓝工程”中青年学术带头人。长期从事微生物与生化药学教学和研究工作，主要研究方向为微生物代谢调控和药物生物合成、抗生素药效学及其机理。主持多项国家、省部级和横向科研课题。至今发表研究论文60余篇，SCI收录24篇，授权发明专利7项，主编出版教材4部。

　　2、研究方向
　　微生物代谢调控和生物活性物质、抗感染药物药效学及机理。

　　3、联系地址
　　中国药科大学，生命科学与技术学院，微生物学教研室；
　　江苏省南京市中央路童家巷24号，邮编210009；
　　Tel.: 025-8327-1323，Fax: 025-8327-1249，E-mail: cl_zhou@cpu.edu.cn

　　4、发表研究论文（近三年）
　　（1）Hui Wang, Mengyun Ke, Yuwei Tian, Jing Wang, Bing Li, Yizhou Wang, Jie Dou, Changlin Zhou*. BF-30 selectively inhibits melanoma cell proliferation via cytoplasmic membrane permeabilization and DNA-binding in vitro and in B16F10-bearing mice. European Journal of Pharmacology. 2013; 707: 1-10 (IF 2.592)
　　（2）Qingru Hao, Hui Wang, Jing Wang, Jie Dou, Min Zhang, Weidong Zhoua, Changlin Zhou*. Effective antimicrobial activity of Cbf-K16 and Cbf-A7A13 against NDM-1-carrying Escherichia coli by DNA binding after penetrating the cytoplasmic membrane in vitro. J. Pept. Sci. 2013; 19: 173–180 (IF 2.071)
　　（3）Kai Chen, Jie Dou, Shirui Tang, Yishun Yang, Hui Wang, Hongqing Fang, Changlin Zhou*. Deletion of the aroK gene is essential for high shikimic acid accumulation through the shikimate pathway in E. coli. Bioresource Technology, 2012 May 29; 119C: 141-147 (IF 4.75)
　　（4）Zhenzhen Su, Jie Dou, Zhipeng Xu, Qinglong Guo, Changlin Zhou*. A novel inhibitory mechanism of baicalein on influenza A/FM1/1/47 (H1N1) virus: interference with mid-late mRNAs synthesis in cell culture. Chinese Journal of Natural Medicines. 2012, 10(6): 415-420 (SCIE)
　　（5）Lu X, Liu X, Wan B, Franzblau SG, Chen L, Zhou C, You Q. Synthesis and evaluation of anti-tubercular and antibacterial activities of new 4-(2,6-dichlorobenzyloxy)phenyl thiazole, oxazole and imidazole derivatives. Part 2. Eur J Med Chem. 2012, 49: 164-171 (IF 3.499)
　　（6）Xitao Cao, Minghua Yang, Jie Dou, Kai Chen, Hui Wang, Tao Xi, Changlin Zhou*. Strain improvement for enhanced production of S-adenosyl-L-methionine in Saccharomyces cerevisiae based on ethionine-resistance and SAM synthetase activity. Ann Microbiol. (2012) 62:1395–1402 (IF 1.549)
　　（7）Mengyu Wang, Hui Wang, Ying Tang, Di Kang, Yu Gao, Mengyun Ke, Jie Dou, Tao Xi , Changlin. Zhou*. Effective inhibition of a Strongylocentrotus nudus eggs polysaccharide against hepatocellular carcinoma is mediated via immunoregulation in vivo. Immunol Lett. 2011 Dec 30; 141(1): 74-82 (IF 2.526)
　　（8）Hui Wang , Mengyu Wang , Jing Chen , Ying Tang, Jie Dou, Jian Yu, Tao Xi, Changlin Zhou* . A Polysaccharides from Strongylocentrotus nudus eggs (SEP) activated splenocytes proliferation in immunosuppressed mice via PI-3k/Akt signaling pathway. International Immunopharmacology, 2011, 11 (11): 1946-1953 (IF 2.376)
　　（9）Lili Chen, Jie Dou, Zhenzhen Su, Huimin Zhou, Hui Wang, Weidong Zhou, Qinglong Guo, Changlin Zhou*. Synergistic activity of baicalein with ribavirin against influenza A (H1N1) virus infections in cell culture and in mice. Antiviral Research. 2011, 91(3): 314-320 (IF 4.301)
　　（10）Huimin Zhou, Jie Dou, Jing Wang, Lili Chen, Hui Wang, Weidong Zhou, Yunman Li, Changlin Zhou*. The antibacterial activity of BF-30 in vitro and in infected burned rats is through interference with cytoplasmic membrane integrity. Peptides. (June, 2011) 32(6): 1131-1138 (IF 2.434)
　　（11）Ren Y, Fang H, Dai H, Li S, Chen H, Zhou C, Yao X. Production of Nalpha-acetylated thymosin alpha1 in Escherichia coli. Microb Cell Fact. 2011 Apr 22;10 (1):26. [Epub ahead of print] (IF 3.552)
　　（12）Jie Dou, Lili Chen, Ge Xu, Lei Zhang, Huimin Zhou, Hui Wang, Zhenzhen Su , Mengyun Ke, Qinglong Guo, Changlin Zhou*. Effects of Baicalein on Sendai Virus In Vivo Are Linked to Serum Baicalin and Its Inhibition of Hemagglutinin-Neuraminidase. Arch Virol (2011), 156(5):793–801（IF 2.111）
　　（13）Ge Xu, Jie Dou, Lei Zhang, Qinglong Guo, Changlin Zhou*. Inhibitory Effects of Baicalein on the Influenza Virus in Vivo Is Determined by Baicalin in the Serum. Biol. Pharm. Bull., 33(2), 238-243, 2010 (IF 1.811)
　　(14)Ying Tang, Mengxiang Ni, Wutong Wu, Jin Sun & Changlin Zhou*. Biotransformation of antitumor intermediate 5-fluorouridine by recombinant E. coli with high pyrimidine nucleoside phosporylase activity. Biocatalysis and Biotransformation, 2010, 28(2), 130-136 (IF 1.275)

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